early 1222: Theodore II Laskaris is born
1233: Betrothal to tsar Ivan II Asen’s daughter, Helen
1235: Marriage of Theodore Laskaris and Helen in Lampsacus
1238, 1241: John III Vatatzes campaigns in Europe. Theodore is in charge of the administration in Asia Minor
December 25th 1250: John (IV Laskaris) is born to Theodore and Helen
November 3rd 1254: John III Vatatzes dies, and Theodore II Laskaris is proclaimed emperor
early 1255: Theodore II Laskaris is crowned emperor by the newly appointed patriarch Arsenios Autoreianos. The Bulgarian tsar Michael II Asen invades Macedonia and Thrace
1255: Georgios Mouzalon becomes megalos domestikos (commander-in-chief of the army)
1255-1256: Theodore II Laskaris campaigns in Europe (Macedonia and Thrace). Relations with the Sultanate of Rum are renewed
May 1256: Peace treaty with the Bulgarian tsar Michael Asen. Prilapo, Velessa, Dibra and Tzepaina return to the control of the Nicaean Empire
October 1256: The daughter of Theodore II Laskaris marries Nicephorus, son of the despotes of Epirus, Michael II
1256: Negotiations with pope Alexander IV for the union of the Churches (1254-61)
1257: The Patriarch Arsenios anathematizes Michael II of Epirus and its people
early 1258: Irene, daughter of Theodore II Laskaris, marries the Bulgarian tsar Constantine Tich. New confrontation with the state of Epirus
Summer of 1258: Theodore II’s health deteriorates. He is tonsured a monk
August 16th 1258: Theodore II Laskaris dies in Nymphaeum