289: Foundation of the province of Osrhoene
314: The province forms part of the diocese of Oriens
363: Surrender of Nisibis to the Persians. Resettlement of the Christian population to the west440: Raids of locusts in Osrhoene. Destructions in the agriculture and famine (440-448)
494-5, 497: Pestilence in Edessa
499, May: Raid of locusts in Osrhoene
ca 500: Famine and pestilence hit the region once again
502: The Bedouins of Hira plunder Osrhoene. Slaughters
502: Raid of the Persians in Osrhoene, with the aid of the Huns and the Bedouins
515, 531: Raids of the Huns in Osrhoene
577: The Persian army raids and burns Osrhoene. Imprisonment of the population
590: Victory of the Byzantines against the Persians near Edessa
602: Edessa is taken by the Persians
628: Edessa is taken by the Byzantines
633: Arab dominance begins to expand in Osrhoene
637: The Arabs besiege Edessa
638: Osrhoene under Arab rule