8-7th century BC: Foundation of the Lydian city
500 BC: Satrapy of Lydia of the Persian Empire
300 BC: Alexander the Great occupies the city
281 BC: Under Seleucid control. The city becomes a Macedonian military colony and is named Thyateira by Seleucus I
275/4 BC: Testimony regarding a recent invasion of the Gauls
190 BC: Battle of Magnesia. Seleucus III loses the area of Lydia.
188 BC: Peace of Apameia. Thyateira become part of the kingdom of Pergamum and Pontus
133 BC: Death of Attalus III. Aristonicus occupies Thyateira.
131 BC: The end of Aristonicus' reign.
84 BC: Suicide of C. Flavius Fimbria at the camp of Thyateira.
80 BC: Thyateira become part of the province of Asia of the Roman empire.
17 AD: A mighty earthquake caused serious damages at Thyateira. Tiberius asked the senatus to help the city.
123 AD: Hadrian visits Thyateira.
215 AD: Visit of Caracalla. Thyateira become a conventus iuridicus.
290 AD approx.: Thyateira become part of the province of Lydia, as a result of Diocletian's administrative reform.