685 BC: Settlement of colonists from Megara
Late 6th century BC: Chalcedon fell into Persian hands
499-494 BC: The city took part in the Ionian Revolt
478 BC: End of the Persian domination
431-404 BC: During the Peloponnesian War, Chalcedon, due to its strategic location, was the field of confrontation between Athenians and Spartans
386 BC: Peace of Antalcidas. Re-establishment of the Persian domination
357 BC: Confederation of Chalcedon and Byzantium
281 BC: The city allied with Byzantium, Heraclea and Mithidrates I, the king of Pontos, aiming at establishing their freedom in view of the expansive tendencies of the Seleucids
202 BC: Philip IV, king of Macedonia, occupied the city
196 BC: Chalcedon was declared a free city by the Romans
73 BC: The city was besieged by Mithidrates VI
258 AD: A Skythian raid
365/6: Destruction of the city by Walis
451: 4th Ecumenical Council