3rd cent. BC.: Foundation of the city of Hierapolis
2nd-3rd cent. AD.: Hierapolis experiences a period of great flourishing
494 AD: A destructive earthquake ravages the city and the wider region
6th cent.: Hierapolis is mentioned as one of the cities in the province of Phrygia Pakatiane
7th-8th cent. AD: The city gradually shrinks in size, as a consequence of the Arab raids
10th cent.: Reference that the city of Hierapolis belongs to the Thracesian theme. The city is relegated to the status of a mere village
10th-12th cent. AD: The city enters a new phase of decline and shrinkage, as a result of the infiltration of the Seljuk Turks in western Asia Minor
c.1190 AD: A destructive earthquake brings about the final depopulation and abandonment of Hierapolis